Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation
نویسندگان
چکیده
ix Chapter I: Introduction DNA DAMAGE RESPONSE 1 DNA DAMAGE REPAIR DNA modifications 3 Repair of double stranded DNA breaks 7 DNA DAMAGE RESPONSE PATHWAYS AND CANCER The link between the FA/BRCA pathway and cancer 8 The FA/BRCA pathway DNA damage response 11 FA/BRCA proteins and DNA damage repair 14 FA/BRCA proteins and cell cycle checkpoint 17 The link between the Mismatch repair pathway and cancer 20 MMR pathway activation 22 MMR proteins and DNA damage repair 23 MMR proteins and checkpoint 24 CONCLUDING REMARKS 26 Chapter II: BACH1 is a DNA repair protein supporting BRCA1 damage response Abstract 28 Introduction 29 Results 31 Discussion 37 Figures 41 Materials and Methods 48 Acknowledgements 51
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